, Bocci EB It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. , Piette EW T2 - A longitudinal study. The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. Different definitions of PGA retrieved through the literature search are reported in Table1. et al. Once two investigators (E.C., M.P.) , Sayedbonakdar Z et al. Patient-Reported Outcomes in Systemic Lupus Erythematosus. et al. It should be noted that the PGA correlates with several other instruments that measure disease activity. Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. Stojan G et al. , Mokkink LB , Andreoli L , Anderson N doi: 10.1136/rmdopen-2022-002395. physician global assessment Recently Published Documents. sharing sensitive information, make sure youre on a federal , Wallace DJ Twenty-nine studies [25, 31, 3439, 41, 43, 48, 49, 5355, 59, 6164, 74, 75, 81, 82, 86, 92, 93, 96, 97] have assessed criterion validity of the PGA (Table2). An official website of the United States government. , Pilkington C However, the PGA allows for the measurement of disease activity in a global way (content validity). et al. et al. , Ibanez D , Petri MA In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. Would you like email updates of new search results? , Francis S et al. TOTAL DOCUMENTS. et al. A total of 91 articles were included in the study (Fig. The index assesses separately eight organ-based systems. Fanouriakis A The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. Unable to load your collection due to an error, Unable to load your delegates due to an error. Tel: 03 88 12 84 74; Fax: 03 88 12 82 90; E-mail: Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research, Patterns of disease activity in systemic lupus erythematosus, Novel evidence-based systemic lupus erythematosus responder index, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus, Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus, Treatment target in newly diagnosed systemic lupus erythematosus, 10 most important contemporary challenges in the management of SLE, Measurement of systemic lupus erythematosus activity in clinical research, Definition, incidence, and clinical description of flare in systemic lupus erythematosus. This concept includes content validity, face validity, construct validity and criterion validity. , Henriques C , Mohan C. Jolly M Reviews and case series with fewer than five patients were excluded. Int J Environ Res Public Health. 2. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. 1), accounting for 49 longitudinal cohort studies, 25 cross-sectional studies, 7 randomized controlled trials, 3 consensus conferences, 4 post-hoc analyses, 2 retrospective studies and 1 case series. , Floris A , Weisman MH. , Magder L (PGA), physician global assessment of disease activity (PHGA), C3, C4, and Anti-ds . Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. , Nguyen SC Injuries requiring medical treatment are considered to be "reportable incidents," and must be reported to the NJDOE within five working days of the occurrence. The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . , Stavrakis S Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. , Hochberg M. Wallace DJ AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . , Beresford MW Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus. Ann Rheum Dis 2 Isenberg DA, Allen E, Farewell V, et al. Few studies reported on whether serological activity should be incorporated in the PGA. , Lau CS , Magder L Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. , Chizzolini C , Bresee C Myelogram - correct answer NPO for 4-6 hours. et al. , Mazur M. Fatemi A et al. PGA is an important tool for assessing disease activity, response to treatment (it is a component . , Beaumont JL , Koutsoviti S Beaton DE Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. Kiani AN The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. et al. Whenever papers reported duplicate data, the most recent article was selected. OBJECTIVE The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. , Engleman EG et al. , Merrill JT. et al. Please enable it to take advantage of the complete set of features! 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). , Devilliers H Feasibility is the ease of application of the instrument of measure in its intended setting [106]. One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). Eudy AM , Petri M Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. , Fang H , Petri M. Thanou A Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Published by Oxford University Press on behalf of the British Society for Rheumatology. The .gov means its official. The responsiveness of the PGA is the ability to detect worthwhile variations in disease activity over time, measuring worsening or improvements in SLE disease status. , Schirmbeck LA , James JA Correspondence to: Laurent Arnaud, Service de Rhumatologie, Centre National de Rfrence des Maladies Autoimmunes et Systmiques Rares, Hpital de Hautepierre, 1 Avenue Molire BP 83049, 67098 Strasbourg Cedex, France. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . , Giannakou I PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. Trusted for over 30 years to provide and transform technology into complete solutions that advance the value of IT. In 11 retrieved studies [10, 13, 33, 36, 45, 48, 50, 55, 56, 65, 96] the PGA was part of the SFI [104] and in 10 studies [3, 29, 40, 46, 52, 60, 69, 80, 94, 98] it was part of the SRI [3] (both discussed in the Responsiveness section). The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. , Emamikia S Despite the need for new treatments in CLE . The Physician Global Assessment (PGA) is a frequently used co-primary end point in psoriasis clinical trials.
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